I seem to spend a lot of time trying to convince people of the value of a clean white or negative space.
Just because you can doesn't mean you should.
Here I am referring to filling in every last ounce of room on your page or artboard.
If you follow the logic that is unused space is waster space, that particular rabbit hole can only finish once a 1pt condensed font is applied and all margins are done away with.
Good design is clever. Good design draws and directs the eyes. Good design gets the right message across and does not clutter with often trivial additional extras.
As always, commercial design needs to consider a range of elements in its make up, and this will have influence on page layout and density. The brand needs to be considered and of course the type of publication.
Don't be afraid of negative space.